The project has three main objectives: 1) To improve the overall prerequisites for the production of microbial agent candidates, which are the subject of exploratory projects of the Helmholtz Centre for Infection Research (HZI) and its international network, in order to be better able to tackle current and future tasks and challenges. 2) To develop, with the aid of the equipment applied for under (1), a sustainable production process for the recently discovered lead structure chlorotonil, which has proved effective against malaria in animal testing, in order to make the substance available so that its pharmacological properties can be optimized. 3) To produce multi-gram amounts of chlorotonil. The work programme consists of three work packages in which production is first of all optimized on a smaller scale, then transferred to stirred fermenters and finally established on a pilot scale. At the same time the corresponding preparation and isolation processes are optimized using the resulting culture broth. In principle, this project can entail applications for intellectual property rights, for example concerning new biotechnological production methods. The rights of third parties are not infringed.

This project is part of the EDCTP2 programme supported by the European Union.