Our consortium of experts in filarial infections from three African countries and two German universities aims to establish a Filarial Clinical Trial & Research Platform (F-CuRE) to conduct the research described in the different work packages of TAKeOFF (Tackling the obstacles to fight filariasis). To initiate F-CuRE in the most effective way with the goal to harmonize the procedure for clinical trials in filariasis, we will perform multinational clinical trials in different countries to improve treatment regimens for morbidity control of LE of filarial and non-filarial (podoconiosis) origins. We aim to strengthen the teaching capacities for scientific and clinical staff by engaging Ministries of Health in the African partner countries, control programmes and WHO throughout the development process.