Multidrug-resistant Enterobacteriaceae (MDR-E) are a major public health threat in many European countries. While traditional infection control strategies primarily target the containment of intra-hospital transmission, growing evidence highlights the importance of inter-hospital patient traffic for the spread of MDR-E within healthcare systems. Going substantially beyond previous research, the EMerGE-NeT consortium will unite expertise in theoretical modelling, numerical simulation studies, epidemiology, clinical medicine, and microbiology in order to develop a generic network modelling platform, which combines inter- and intra-hospital transmission of MDR-E in a single framework.