This TB cohort, Research Task (RT) 1, serves as a platform for four other RTs: RT2 Host - Immunology Study, RT3 Pathogen Study, RT4 Socio-economic Study und RT5 Intervention Study. All the RTs comprise activities for developing administrative, infrastructural, medical and/or scientific capacities which are intended to enable research and treatment of tuberculosis based in Africa in the long term. Another important component of TB Sequel activities is collaboration in and expansion of scientific networks, which is intended to promote contacts and exchange among African scientists as well as to make them part of the global TB research community.